Iran's Revolutionary Guards has carried out attacks against a US base in Jordan and 21 other targets in the Gulf on Wednesday in retaliation for American strikes around the Strait of Hormuz, Iranian media reported.
The clashes mark one of the biggest exchanges in hostilities since the two countries agreed to a ceasefire in April.
The Iranian strikes, which included attacks in Kuwait and Bahrain, came after the US military said on X it had targeted Iranian air defence, ground control stations and surveillance radar sites near the strait in response to what President Donald Trump said was the downing of a US Apache helicopter on Tuesday.
"I believe the response should be very strong, very powerful, and that's what this one is," Trump told ABC News on Tuesday.
The escalation in violence deepens doubts about the prospects for a deal to end the war that started on February 28 with joint US-Israeli strikes against Iran.
Tehran responded by firing on Gulf neighbours that host US bases and all but choked off the Strait of Hormuz, a vital conduit for oil and gas.
The latest US strikes lasted around four hours before the US Central Command posted just before 9 pm ET (0100 GMT Wednesday) that they had ended. A US official said almost 20 Iranian targets had been struck.
Iran's state media reported that Qeshm island and the port city of Sirik in the Strait of Hormuz were attacked.
Sounds of explosions were heard in nearby Bandar Abbas, and later in the vicinity of Jask, near the entrance to the strait, Iranian media reported, citing local sources and residents.
Iran's Revolutionary Guards said in response they had targeted four sites at the US al-Azraq base in Jordan using long-range missiles, Iranian media reported.
The Guards said the targets included F-35 fighter jet hangars and a command-and-control centre, and warned they were ready to deliver a "crushing and decisive" response to any further US attack.
Jordanian armed forces said on Wednesday they had intercepted and shot down five missiles launched from Iran toward al-Azraq. The military added that debris from the interception operation fell on Jordanian territory but caused no injuries or material damage.
The Kuwaiti army said its air defence systems were engaging hostile aerial targets and urged the public to follow official safety instructions, after Iran's Revolutionary Guards said they had targeted the Ali Al Salem base in Kuwait with drones.
Iran's Revolutionary Guards said earlier they attacked the US Fifth Fleet in Bahrain with drones and threatened "more severe responses" if hostilities continued, according to media.
Bahrain's Interior Ministry said a warning siren had been sounded and urged the public to head to safety. Air defences had repelled Iranian attacks, a media adviser to Bahrain's king said soon after in a post on X.
A US official, speaking on condition of anonymity, said initial assessments showed nearly all missiles and drones launched by Iran were intercepted and they were not immediately aware of any reports of harm to personnel or damage to locations.
The Pentagon did not immediately respond to a request for comment. Reuters could not immediately verify the battlefield reports.
Oil prices climbed about 1 per cent in early Asian trade on Wednesday following the escalation in hostilities.

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