Novak Djokovic begins his Australian Open title defence against Jeremy Chardy after the draw for the year's first Grand Slam was made on Friday.
World number one Djokovic captured a record-extending eighth title at Melbourne Park last year by beating Dominic Thiem, who is seeded third and faces Mikhail Kukushkin.
Rafael Nadal, seeking a first title at the major since 2009, faces Laslo Djere in his opener.
Reigning women's champion Sofia Kenin will meet wildcard Maddison Inglis.
Top-ranked Ash Barty resumes her quest to become the first homegrown singles winner at the Australian Open since 1978 when the 24-year-old takes on Danka Kovinic.
American Serena Williams, looking to win a record-equalling 24th Grand Slam, meets Laura Siegemund in the opening round while 2019 champion Naomi Osaka faces Anastasia Pavlyuchenkova.
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