England beat Ireland and France by 12 and 36 points respectively in their first two matches of the campaign.
They are currently ranked third in the world.
Play from the Millennium Stadium in Cardiff gets underway at 8:45 PM UAE time.
Meanwhile Scotland travel to France for their latest Six Nations fixture.
Action from the Stade de France starts at 6:15 PM UAE time.
Britain's Draper to miss French Open with ongoing knee injury
Briton Jack Draper will not compete at next month's French Open as he continues to recover from a knee injury, the former world number four said on Wednesday.
Clinical Sinner holds off wildcard Jodar to reach Madrid Open semis
World number one Jannik Sinner held off 19-year-old wildcard Rafael Jodar to win 6-2 7-6(0) in the Madrid Open quarter-finals on Wednesday, becoming the sixth player to reach the semi-finals of all nine ATP 1000 Masters tournaments.
LIV Golf touts 'strong momentum' despite New Orleans postponement
LIV Golf said the league looks forward to continuing its "strong momentum" despite postponing its New Orleans event scheduled for June amid questions about its future beyond 2026.
Baptiste's variety drags Sabalenka out of comfort zone in Madrid shock
Hailey Baptiste offered a glimpse of how Aryna Sabalenka can be unsettled on clay after mixing forays to the net with changes of pace to save six match points and prevail over the world number one in their Madrid Open quarter-final on Tuesday.
FIFA to increase financial distribution to all 48 World Cup teams by 15%
Amid widespread complaints about the cost of tickets and transportation related to World Cup games, FIFA announced Tuesday that it will hike the money received by all 48 teams participating this summer by 15 per cent.
US President Donald Trump has welcomed the UAE's decision to exit OPEC, telling reporters on Wednesday that he thinks the move could help lower oil prices.
UAE President His Highness Sheikh Mohamed bin Zayed Al Nahyan has congratulated Ali Al Zaidi on his designation to form a new government in Iraq during a phone call on Wednesday.
Dubai Police have led a major international operation targeting transnational financial crime, resulting in the arrest of 276 suspects and the dismantling of nine criminal centres linked to investment fraud and virtual currency scams.
