According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Dalic named UAE coach after leaving Croatia
Croatian manager Zlatko Dalic has been appointed coach of the UAE, the country's football association (UAEFA) said on Wednesday.
Rybakina fights back to beat Osaka at Canadian Open
Second seed Elena Rybakina has fought back from a set and a break down to prevail 4-6 7-6(5) 6-4 in her Canadian Open quarter-final against Naomi Osaka in Toronto on Tuesday.
Egypt's Trezeguet joins Saudi side Al-Riyadh on free transfer
Egypt winger Mahmoud Hassan, better known by his nickname "Trezeguet", has joined Saudi Pro League club Al-Riyadh on a free transfer after terminating his contract with Egyptian side Al-Ahly last month, the club announced on Tuesday.
Shelton routs Mensik to reach Canadian Open semis
Ben Shelton has produced one of the standout performances of his career on Tuesday, overpowering Jakub Mensik 6-3 6-1 to reach the Canadian Open semi-finals as the American builds momentum ahead of the US Open.
Afghanistan seal 2027 World Cup berth, West Indies to go through qualifiers again
Afghanistan secured automatic qualification for the 2027 World Cup with a win over Ireland on Monday, leaving twice champions West Indies to go through qualifiers for the third successive edition of the 50-overs tournament.
UAE President His Highness Sheikh Mohamed bin Zayed Al Nahyan has held talks with Bahrain’s King Hamad bin Isa Al Khalifa during his fraternal visit to the UAE.
Marking International Youth Day, UAE President His Highness Sheikh Mohamed bin Zayed Al Nahyan has led messages emphasising the central role young people play in "achieving a future in which opportunity can grow for all".
The UAE has proposed five priorities to strengthen education cooperation among BRICS countries.
