Liverpool suffered their first defeat in the Premier League this season, going down 3-0 at Watford.
All the goals came in the second-half with Ismaila Sarr scoring a double and Troy Deeney netting his side's third.
Jurgen Klopp's men missed the chance of setting a top-flight record of 19 straight victories and were five games away from equalling Arsenal's all-time best unbeaten run of 49 matches.
The win helped Watford move out of the relegation places.
West Ham also climbed out of the bottom three with a 3-1 win over Southampton, while Bournemouth are now in the drop zone after their 2-2 draw at home to Chelsea.
Elsewhere, Newcastle finished 0-0 with Burnley and Brighton lost 1-0 at home to Crystal Palace.
In Sunday's games, Tottenham host Wolves and Manchester United head to Everton.


Volkanovski secures quick win over Evloev at Abu Dhabi's UFC 333
Hamilton fastest to complete Ferrari's US Grand Prix practice sweep
Gabriel shines at both ends as Arsenal ease past Everton to go level with Man City
Jackson double ends Man City's perfect run as Villa win
Varma leads India fightback in four-wicket victory over New Zealand
