Syria's President Bashar al-Assad and his wife Asma have tested positive for COVID-19 after showing minor symptoms, his office said on Monday.
The pair are in good health and would keep working in isolation at home, the statement said.
Syria has seen a sharp rise in infections since mid-February. Health and aid officials say it remains difficult to gauge the full size of the outbreak given the lack of testing facilities in a fragile health system devastated by a decade of war.
Assad joins a growing list of world leaders who have tested positive for COVID-19, alongside Britain's Boris Johnson, France's Emmanuel Macron and former U.S. President Donald Trump.
Health workers said the authorities underplayed the size of the outbreak for most of last year, when official figures remained low as hospitals were overwhelmed and death notices appeared in newspapers.
The government denied undercounting the figures and has acknowledged in the last two months the country could be on the verge of a major spike.
It has urged people to wear face masks, take sanitary measures and avoid crowded areas.
President Donald Trump has signed an executive order terminating a US sanctions programme on Syria, allowing an end to the country's isolation from the international financial system and building on Washington's pledge to help it rebuild after a devastating civil war.
Former criminology graduate student Bryan Kohberger has agreed to plead guilty to killing four Idaho college students in 2022, a move that would spare him the death penalty under a deal with prosecutors, according to the family of one of the victims.
US President Donald Trump plans to host Israeli Prime Minister Benjamin Netanyahu at the White House on July 7, a US official said, as the American leader pressed for a ceasefire between Israel and Hamas in Gaza, and the return of remaining hostages.
The Israeli military acknowledged on Monday that Palestinian civilians were harmed at aid distribution centres in the Gaza Strip, saying that new instructions had been issued to Israeli forces following "lessons learned".
Palestinians in northern Gaza reported one of the worst nights of Israeli bombardment in weeks after the military issued mass evacuation orders on Monday, while Israeli officials were due in Washington for a new ceasefire push by the Trump administration.
Sheikh Abdullah bin Zayed Al Nahyan, Deputy Prime Minister and Minister of Foreign Affairs, on Tuesday had a phone call with the Director General of the International Atomic Energy Agency (IAEA), Rafael Grossi, discussing ways to cooperate, as well as regional developments.
A programme has been launched to prepare Emirati youth to take part in UAE-led social missions around the world, including humanitarian, developmental and cultural.