Syria's President Bashar al-Assad and his wife Asma have tested positive for COVID-19 after showing minor symptoms, his office said on Monday.
The pair are in good health and would keep working in isolation at home, the statement said.
Syria has seen a sharp rise in infections since mid-February. Health and aid officials say it remains difficult to gauge the full size of the outbreak given the lack of testing facilities in a fragile health system devastated by a decade of war.
Assad joins a growing list of world leaders who have tested positive for COVID-19, alongside Britain's Boris Johnson, France's Emmanuel Macron and former U.S. President Donald Trump.
Health workers said the authorities underplayed the size of the outbreak for most of last year, when official figures remained low as hospitals were overwhelmed and death notices appeared in newspapers.
The government denied undercounting the figures and has acknowledged in the last two months the country could be on the verge of a major spike.
It has urged people to wear face masks, take sanitary measures and avoid crowded areas.
Israeli planes and tanks pounded the eastern and northern outskirts of Gaza City overnight Saturday to Sunday, destroying buildings and homes, residents said, as Israeli leaders vowed to press on with a planned offensive on the city.
The Pentagon is working on plans to deploy the US military to Chicago as President Donald Trump says he is cracking down on crime, homelessness and undocumented immigration, the Washington Post reported on Saturday.
Thousands of Australians joined pro-Palestinian rallies on Sunday, organisers said, amid strained relations between Israel and Australia following the centre-left government's decision to recognise a Palestinian state.
North Korean leader Kim Jong Un supervised the firing of new air defence missiles to test their combat capability, state media KCNA reported on Sunday.
Portugal's authorities have said that between July 27 and August 15, 1,331 excess deaths from extreme heat were reported, with the over 75 age group particularly hard hit, Euronews reported on Saturday.
Access to Dubai International Airport's Terminal 1 is set to improve under a new contract awarded by Dubai's Roads and Transport Authority (RTA) to widen the existing bridge from three to four lanes.
A UAE aid convoy, loaded with critical food and relief supplies, has arrived in Gaza to address the urgent needs of Palestinians displaced by the conflict, state news agency Wam reported.