Syria's President Bashar al-Assad and his wife Asma have tested positive for COVID-19 after showing minor symptoms, his office said on Monday.
The pair are in good health and would keep working in isolation at home, the statement said.
Syria has seen a sharp rise in infections since mid-February. Health and aid officials say it remains difficult to gauge the full size of the outbreak given the lack of testing facilities in a fragile health system devastated by a decade of war.
Assad joins a growing list of world leaders who have tested positive for COVID-19, alongside Britain's Boris Johnson, France's Emmanuel Macron and former U.S. President Donald Trump.
Health workers said the authorities underplayed the size of the outbreak for most of last year, when official figures remained low as hospitals were overwhelmed and death notices appeared in newspapers.
The government denied undercounting the figures and has acknowledged in the last two months the country could be on the verge of a major spike.
It has urged people to wear face masks, take sanitary measures and avoid crowded areas.
The United States expressed confidence that peace talks with Iran would go ahead in Pakistan and a senior Iranian official said Tehran was considering joining, but significant hurdles and uncertainty remained as the end of a ceasefire loomed.
A gunman shot one dead as he opened fire at Mexico's Teotihuacan pyramids on Monday before taking his own life, authorities said, in a rare attack at a major tourist attraction.
Iran is considering attending peace talks with the United States in Pakistan, a senior Iranian official told Reuters on Monday, following moves by Islamabad to end a US blockade of Iran's ports, a major hurdle for Iran to rejoin peace efforts.
Israeli strikes have killed at least five Palestinians in separate incidents in the Gaza Strip on Monday, Palestinian health officials said, while fighters from Hamas clashed with gunmen from an Israeli-backed militia, witnesses said.
President Donald Trump said on Monday he believed a nuclear deal the US is currently negotiating with Iran will be better than a 2015 international agreement to curb Tehran's nuclear programme.
His Highness Sheikh Mohammed bin Rashid Al Maktoum, Vice President and Prime Minister of the UAE and Ruler of Dubai, has reviewed the AED3billion Beach Development Plan to turn Dubai into the world's best city to live in by 2040.
UAE President His Highness Sheikh Mohamed bin Zayed Al Nahyan has reviewed national plans with His Highness Sheikh Saud bin Saqr Al Qasimi, Supreme Council Member and Ruler of Ras Al Khaimah, in a meeting on Tuesday.