Syria's President Bashar al-Assad and his wife Asma have tested positive for COVID-19 after showing minor symptoms, his office said on Monday.
The pair are in good health and would keep working in isolation at home, the statement said.
Syria has seen a sharp rise in infections since mid-February. Health and aid officials say it remains difficult to gauge the full size of the outbreak given the lack of testing facilities in a fragile health system devastated by a decade of war.
Assad joins a growing list of world leaders who have tested positive for COVID-19, alongside Britain's Boris Johnson, France's Emmanuel Macron and former U.S. President Donald Trump.
Health workers said the authorities underplayed the size of the outbreak for most of last year, when official figures remained low as hospitals were overwhelmed and death notices appeared in newspapers.
The government denied undercounting the figures and has acknowledged in the last two months the country could be on the verge of a major spike.
It has urged people to wear face masks, take sanitary measures and avoid crowded areas.
US President Donald Trump on Sunday called on Ukrainian President Volodymyr Zelenskiy to stop targeting Russian diesel infrastructure, saying the attacks were causing a shortage of the fuel that is "hurting the world".
Indonesian rescuers were searching on Sunday for 130 people from a passenger ship that sank in the Java Sea after 113 others were evacuated, the country's search and rescue agency said, adding that six people had died.
At least five people were wounded in a Russian attack on the Ukrainian city of Odesa on Sunday morning, officials said, a day after strikes on the city killed two people.
Authorities in the Philippines said on Sunday it could take weeks or months to identify the victims of a ferry fire that killed 76 people, as forensic experts begin collecting and comparing DNA samples and investigators determine the cause.
UAE President His Highness Sheikh Mohamed bin Zayed Al Nahyan welcomed King Abdullah II bin Al Hussein of Jordan upon his arrival in Abu Dhabi on Sunday.
His Highness Sheikh Hamdan bin Mohammed bin Rashid Al Maktoum, Crown Prince of Dubai and Deputy Prime Minister, has approved an official of the rank of Director-General as the first recipient of the Mohammed bin Rashid Leadership Medal.
Dr Anwar Gargash, diplomatic advisor to the UAE president, on Sunday said the meeting between Abu Dhabi Crown Prince His Highness Sheikh Khaled bin Mohamed bin Zayed Al Nahyan and Iranian President Dr Masoud Pezeshkian reflects the UAE's stance of "deterrence and diplomacy".