Syria's President Bashar al-Assad and his wife Asma have tested positive for COVID-19 after showing minor symptoms, his office said on Monday.
The pair are in good health and would keep working in isolation at home, the statement said.
Syria has seen a sharp rise in infections since mid-February. Health and aid officials say it remains difficult to gauge the full size of the outbreak given the lack of testing facilities in a fragile health system devastated by a decade of war.
Assad joins a growing list of world leaders who have tested positive for COVID-19, alongside Britain's Boris Johnson, France's Emmanuel Macron and former U.S. President Donald Trump.
Health workers said the authorities underplayed the size of the outbreak for most of last year, when official figures remained low as hospitals were overwhelmed and death notices appeared in newspapers.
The government denied undercounting the figures and has acknowledged in the last two months the country could be on the verge of a major spike.
It has urged people to wear face masks, take sanitary measures and avoid crowded areas.
A state of relative calm prevailed around the Strait of Hormuz on Saturday, after days of sporadic flare-ups, as the United States waited for Iran's response to its latest proposals to end more than two months of fighting and begin peace talks.
A car bombing at a police post killed at least three officers in northwestern Pakistan on Saturday and was followed by an ambush on police personnel rushing to the scene to provide backup, security officials said.
An Israeli strike on the southern Lebanese town of Saksakiyeh killed at least seven people, including a child, and wounded 15 on Saturday, Lebanon's health ministry said.
The cruise ship hit by a deadly hantavirus outbreak arrived early on Sunday near the Port of Granadilla in Tenerife, Reuters footage showed, where it will anchor for the evacuation of the passengers and some of the crew.
Centre-right leader Peter Magyar was sworn in as Hungary's prime minister on Saturday, propelled into office on promises of change after years of economic stagnation and strained ties with key allies under his predecessor Viktor Orban.
His Highness Sheikh Abdullah bin Zayed Al Nahyan, Deputy Prime Minister and Minister of Foreign Affairs, has expressed the UAE's support for Bahrain after authorities there said they had uncovered a cell linked to Iran’s Islamic Revolutionary Guard Corps (IRGC).
President His Highness Sheikh Mohamed bin Zayed Al Nahyan has sent a message of congratulations to Péter Magyar on the occasion of taking the oath of office as Prime Minister of Hungary.
His Highness Sheikh Abdullah bin Zayed Al Nahyan, Deputy Prime Minister and Minister of Foreign Affairs, discussed with Margus Tsahkna, Minister of Foreign Affairs of Estonia, on Saturday, the latest regional developments and the repercussions of Iranian attacks targeting civilian sites and facilities in the UAE.