The World Health Organisation has said it has lost communication with its contacts in Al Shifa hospital in northern Gaza.
In a statement it expressed its deep concern about the safety of health workers and hundreds of sick and injured people, including children in nurseries and displaced persons, who remain inside.
The hospital is the largest medical complex in Gaza.
According to the latest reports, the number of in-patients is almost double the hospital's capacity, although services are limited to emergency care needed to save lives.
The organisation reiterated its call for an immediate ceasefire in Gaza "as the only way to save lives and put an end to the horrific suffering there".
Saudi confirms attempted attack on oil refinery, no damage
UN 'deeply disturbed' by strike on Iran school that killed 160 children
At least four killed in Israeli strike on building in Lebanon's Baalbek
Kuwait announces death of child from shrapnel wound
Philippine lawmakers advance impeachment of Vice President Duterte
