The United States has evacuated more than 300 citizens out of Wuhan.
The two flights left the Chinese city on Tuesday after the passengers were screened.
In a statement, the US State Department said the passengers will be subject to "Centres for Disease Control (CDC) screening, health observation, and monitoring requirements" upon arrival at one of two California military bases.
Authorities added that more flights for US citizens in Wuhan could be scheduled for Thursday.
It comes as China criticised the US of spreading fear over the coronavirus outbreak.
Shooting at Australia's Bondi Beach kills 12
Police hold person of interest after Brown University shooting leaves two dead
Hamas says Israel's killing of senior commander threatens ceasefire
Ukraine's Zelenskyy ditches NATO ambition ahead of peace talks
Thailand declares curfew along coast as Cambodia border fighting spreads
