Arsenal and Chelsea made it through to the Europa League last-eight while Inter and Sevilla were knocked out.
Arsenal are into the quarter-finals of the Europa League after beating Rennes 3-0 at the Emirates Stadium.
Pierre-Emerick Aubameyang scored twice and set-up Ainsley Maitland-Niles as the Gunners overturned a two-goal deficit from the first leg, progressing 4-3 overall.
They're joined in the last-eight by London rivals Chelsea, who thrashed Dynamo Kiev 5-0 away from home to complete an 8-0 aggregate victory.
Olivier Giroud claimed a hat-trick, with Marcus Alonso and Callum Hudson-Odoi also getting on the scoresheet.
Italian giants Internazionale were knocked out by Eintracht Frankfurt as Luka Jovic got the only goal of the tie for the German outfit at the San Siro.
That wasn't the only shock result however, as Spanish side Sevilla, who have won the competition a record five times, lost 4-3 to Slavia Prague after extra-time to go out 6-5 on aggregate.
Elsewhere, Villarreal beat Zenit St Petersburg 2-1 to complete a 5-2 aggregate win, Benfica overturned a 1-0 deficit from the first leg to beat Dinamo Zagreb 3-1 overall and Valencia secured a 1-1 draw at Krasnador to progress 3-2.
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