According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Arsenal must improve defensively despite win over Wolves, says Arteta
Arsenal manager Mikel Arteta let rip at his players following their 2-1 Premier League home win over Wolverhampton Wanderers, saying their "horrible defensive habits" made the margin of victory narrower than it should have been.
Dubai Capitals secures thrilling nine-run victory over Abu Dhabi Knight Riders
The Dubai Capitals fended off the Abu Dhabi Knight Riders to secure a nine-run victory at the Zayed Cricket Stadium on Saturday.
Dominant pitching leads Mid East to series saving win over Mumbai
Kazuki Yabuta struck out eight and allowed only four hits and one run in 6.1 innings, and Haru Yoshioka had a perfect 2.2 relief with seven strikeouts, including a Fire Ball strikeout to end the game, to give Mid East Falcons the win 5-1 over Mumbai Cobras and tie the United Series (1-1).
Police detain organiser of Messi visit after Indian fans rip up seats
Lionel Messi's tour of India kicked off chaotically on Saturday as fans threw objects, ripped up seats and invaded the pitch at Kolkata's Salt Lake stadium after the Argentine soccer great made only a brief appearance at a ticketed event.
Patel dominates as Mumbai take Game 1 of United Series
Karan Patel’s dominant pitching display and a solo home run from Miguel Ojeda Jr. powered the Mumbai Cobras to a 3–1 victory over the Mid East Falcons in Game 1 of the United Series.
UAE President His Highness Sheikh Mohamed bin Zayed Al Nahyan has started his official visit to Cyprus with a reception ceremony held by President of Cyprus, Nikos Christodoulides, at the Presidential Palace in Nicosia.
Several parts of the UAE have been hit with rainfall of varying intensities on Sunday morning, with the Dubai Police issuing public safety messages via SMS to urge residents to exercise caution.
The UAE has strongly condemned the terrorist shooting at a Jewish gathering in Australia's Bondi Beach that left at least 12 people dead and around 30 more wounded.
