Liverpool suffered their first defeat in the Premier League this season, going down 3-0 at Watford.
All the goals came in the second-half with Ismaila Sarr scoring a double and Troy Deeney netting his side's third.
Jurgen Klopp's men missed the chance of setting a top-flight record of 19 straight victories and were five games away from equalling Arsenal's all-time best unbeaten run of 49 matches.
The win helped Watford move out of the relegation places.
West Ham also climbed out of the bottom three with a 3-1 win over Southampton, while Bournemouth are now in the drop zone after their 2-2 draw at home to Chelsea.
Elsewhere, Newcastle finished 0-0 with Burnley and Brighton lost 1-0 at home to Crystal Palace.
In Sunday's games, Tottenham host Wolves and Manchester United head to Everton.
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